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KMID : 1100220070060020048
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Dementia and Neurocognitive Disorders
2007 Volume.6 No. 2 p.48 ~ p.53
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Cognitive Dysfunctions in Parkinson’s Disease: Observations Using the CANTAB
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Chung Sun-Ju
Lee Jae-Hong
Lee Tae-Yeon
Sung Young-Hee
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Abstract
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Background: Dementia has been increasingly recognized to be a common clinical manifestation in patients with Parkinson’s disease (PD). Dementia in PD may be mediated by dopaminergic deficits or cholinergic deficits, biochemically, and cortical Lewy bodies or senile plaque, pathologically. We aimed to explore a reliable clinical test assessing cognitive dysfunction in patients with PD.
Methods: Cambridge Neuropsychological Tests Automated Battery (CANTAB) Paired Association Learning (PAL) test and Reaction Time (RTI) test were performed in 56 PD patients, 22 subjects with amnestic mild cognitive impairment (aMCI), and 19 normal controls. Among 56 PD patients, 30 patients were PD with no dementia (PDND) and 26 were PD with dementia (PDD). Unified Parkinson’s Disease Rating Scale (UPDRS) motor scores were used in the analysis as an indicator of dopamine depletion in the striatum.
Results: In the PDND group, there was a significant correlation between Korean version of Mini-Mental State Examination (KMMSE) scores and UPDRS motor scores (p=0.022). In the PDD group, K-MMSE scores correlated significantly with both PAL scores (p=0.047) and RTI scores (p=0.047). In subjects with aMCI, K-MMSE scores showed a significant correlation with PAL scores (p=0.002) but not with RTI scores.
Conclusions: Our data showed that cognitive dysfunction in PDND is associated with striatal dopamine depletion as estimated by UPDRS, and cognitive dysfunction in PDD is mediated by a non-dopaminergic mechanism. These findings suggested that CANTAB may be useful in detecting non-dopamine-mediated cognitive dysfunction in PD.
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KEYWORD
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Parkinson’s disease, Dementia, Dopamine, Acetylcholine, Cambridge Neuropsychological Tests Automated Battery
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